{"id":927,"date":"2020-01-09T18:22:24","date_gmt":"2020-01-09T18:22:24","guid":{"rendered":"http:\/\/lightox.co.uk\/?page_id=927"},"modified":"2024-09-05T10:56:58","modified_gmt":"2024-09-05T10:56:58","slug":"lxd191","status":"publish","type":"page","link":"https:\/\/lightox.co.uk\/lxd191\/","title":{"rendered":"LXD191"},"content":{"rendered":"
[vc_row thb_full_width=”true” thb_row_padding=”true” thb_column_padding=”true” content_placement=”middle” parallax=”content-moving” parallax_speed_bg=”1.6″ el_class=”top-row” css=”.vc_custom_1625561231526{padding-bottom: 10vh !important;background-image: url(https:\/\/lightox.co.uk\/wp-content\/uploads\/2020\/01\/LIGHTOX_PDT.jpg?id=1470) !important;background-position: center;background-repeat: no-repeat !important;background-size: cover !important;}” el_id=”header” bg_gradient1=”rgba(50,0,130,0.35)” bg_gradient2=”rgba(50,0,130,0.45)”][vc_column thb_color=”thb-light-column” offset=”vc_col-lg-11″][vc_empty_space mobile_height=”7vh” height=”12vh”][vc_row_inner][vc_column_inner thb_color=”thb-light-column” width=”1\/4″ css=”.vc_custom_1578433242029{padding-right: 3vw !important;}”][\/vc_column_inner][vc_column_inner thb_color=”thb-light-column” width=”3\/4″ css=”.vc_custom_1578594891004{padding-top: 8vh !important;}”][vc_column_text animation=”animation bottom-to-top”]\n
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THERAPEUTICS\u00a0 <\/span>\u00a0I\u00a0\u00a0 LXD191<\/h6>\n<\/div>\n[\/vc_column_text][vc_column_text]\n

We are developing a light activated treatment.<\/span><\/span><\/h1>\n[\/vc_column_text][vc_column_text animation=”animation bottom-to-top”]\n

LightOx lead candidate LXD191 is formulated to be applied topically to pre-cancerous lesions in the oral cavity. It is activated by light and induces toxicity in the cells of interest, leading to apoptosis and cell death within the area. This local delivery mechanism, combined with targeted light activation gives greater control to the clinicians and minimises off-target effects to surrounding healthy tissues.<\/span><\/b><\/span><\/strong><\/p>\n[\/vc_column_text][vc_empty_space height=”2vh”]\t\n\t\tLearn More<\/span>\n\t\t\t<\/a>\n\t\t[vc_empty_space height=”6vh”][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row thb_full_width=”true” thb_row_padding=”true” thb_column_padding=”true” content_placement=”top” css=”.vc_custom_1625225681279{padding-top: 3vh !important;background-color: #ffffff !important;}” thb_divider_color=”#ffffff” thb_divider_height=”100″ el_class=”align-center” el_id=”LXD191″][vc_column el_class=”align-center” offset=”vc_col-lg-9″][vc_row_inner][vc_column_inner][vc_empty_space height=”8vh”][vc_column_text animation=”animation bottom-to-top”]\n

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LXD191<\/span>
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We are developing a treatment that will be applied directly to the diseased area, in the form of a gel, <\/span>and is activated using a specific wavelength of light.<\/span><\/h2>\n[\/vc_column_text][vc_empty_space height=”2vh”][\/vc_column_inner][\/vc_row_inner][vc_row_inner][vc_column_inner css=”.vc_custom_1625227432419{padding-right: 3vw !important;}”][vc_column_text css=”” animation=”animation bottom-to-top”]\n
We have seen positive results in pre-clinical animal studies and are looking to move into the clinic towards the end of 2025. We envisage this treatment will provide a convenient way of managing patients with oral dysplasia and reduce their risk of developing mouth cancer.<\/h5>\n[\/vc_column_text][vc_empty_space height=”2vh”][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row thb_full_width=”true” thb_row_padding=”true” thb_column_padding=”true” css=”.vc_custom_1625239452832{padding-top: 3vh !important;background-color: #ffffff !important;}” thb_divider_color=”#ffffff” thb_divider_height=”100″ el_class=”align-center”][vc_column el_class=”align-center” offset=”vc_col-lg-9″][vc_row_inner][vc_column_inner][vc_text_separator title=””][vc_empty_space height=”3vh”][vc_column_text animation=”animation bottom-to-top”]\n

Our Solution<\/span><\/h3>\n[\/vc_column_text][vc_empty_space height=”3vh”][vc_column_text animation=”animation bottom-to-top”]\n
LightOx\u2019s new technologies fundamentally change the way in which light-based therapies are delivered to the patient through a new class of patented small molecule, fluorescent, multi-functional compounds which overcome the limitations of current light-based treatments.<\/h5>\n

Particularly appropriate for the treatment of pre-cancerous and early stage oral cancer, this light-based therapeutic treatment minimises side-effects for patients and is less invasive than surgery.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner][vc_column_inner width=”1\/3″ animation=”animation bottom-to-top” css=”.vc_custom_1578785342773{padding-top: 3vh !important;}”][vc_single_image image=”1443″ img_size=”full” alignment=”center”][vc_column_text animation=”animation bottom-to-top”]\n

Apply<\/b><\/h3>\n[\/vc_column_text][vc_column_text animation=”animation bottom-to-top”]\n
Small compound size suitable for topical formulation
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Cell penetration using small molecule drug<\/span><\/h5>\n[\/vc_column_text][vc_separator][\/vc_column_inner][vc_column_inner width=”1\/3″ animation=”animation bottom-to-top” css=”.vc_custom_1578785355343{padding-top: 3vh !important;}”][vc_single_image image=”1445″ img_size=”full” alignment=”center”][vc_column_text animation=”animation bottom-to-top”]\n

Target<\/b><\/h3>\n[\/vc_column_text][vc_column_text animation=”animation bottom-to-top”]\n
The cancerous area is identified
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There is minimal collateral damage<\/span><\/h5>\n[\/vc_column_text][vc_separator][\/vc_column_inner][vc_column_inner width=”1\/3″ animation=”animation bottom-to-top” css=”.vc_custom_1578785361383{padding-top: 3vh !important;}”][vc_single_image image=”1446″ img_size=”full” alignment=”center”][vc_column_text]\n

Treat<\/b><\/h3>\n[\/vc_column_text][vc_column_text animation=”animation bottom-to-top”]\n
Increased light power on targeted area activates cell killing
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Natural mechanism: ROS production leads to cell apoptosis<\/span><\/h5>\n[\/vc_column_text][vc_separator][\/vc_column_inner][\/vc_row_inner][vc_empty_space height=”15vh”][\/vc_column][\/vc_row][vc_row thb_full_width=”true” thb_row_padding=”true” thb_column_padding=”true” content_placement=”top” css=”.vc_custom_1625494688918{padding-top: 15vh !important;background-color: #edf2f4 !important;}” thb_divider_color=”#ffffff” thb_divider_height=”100″ el_class=”align-center”][vc_column el_class=”align-center” offset=”vc_col-lg-9″][vc_empty_space height=”3vh”][vc_row_inner][vc_column_inner][vc_column_text animation=”animation bottom-to-top”]\n

The treatment could be as simple as:<\/span> dentist\u2019s standard oral inspection, in-surgery treatment, repeated as necessary.<\/span>
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Non-invasive treatment of oral squamous cell carcinoma by inducing apoptosis (natural cell death) of the selected cells and tissues with minimal damage to healthy cells.<\/h5>\n[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_empty_space height=”3vh”][vc_row_inner][vc_column_inner width=”1\/2″][vc_column_text css=”.vc_custom_1725533809822{padding-right: 2vw !important;}”]Important advancements include:<\/strong><\/p>\n
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  1. Small molecule, ideal for topical application<\/li>\n
  2. Minimal off-target toxicity<\/li>\n
  3. Non-toxic in the absence of light activation<\/li>\n
  4. Rapid uptake in cancer cells, reducing the exposure time to the drug and speeding up light-based treatment times<\/li>\n<\/ol>\n[\/vc_column_text][\/vc_column_inner][vc_column_inner width=”1\/2″][vc_column_text]Our phototherapeutic drugs precisely target diseased tissues and, by using light-based treatment, only these areas are activated, enabling rapid treatment and destruction of specific cells and tissues.<\/p>\n

    We are building relationships with clinicians working in the oral cancer and phototherapeutic areas to ensure that our ongoing development programme keeps patients at the heart of everything we do. We are working to ensure that our novel treatment is as simple and user-friendly as possible for both clinicians to use and patients to experience.<\/p>\n

    We are actively seeking new partners in the area of Head and Neck cancer especially those who have experience working with Photodynamic Therapies.<\/strong>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_empty_space height=”8vh”][vc_row_inner][vc_column_inner el_class=”text-center”][vc_column_text animation=”animation bottom-to-top”]\n

    Get in touch to start a conversation with our team<\/span><\/h3>\n[\/vc_column_text][vc_empty_space height=”1vh”]\t\n\t\tCONTACT<\/span>\n\t\t\t<\/a>\n\t\t[vc_empty_space height=”15vh”][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row thb_full_width=”true” thb_row_padding=”true” thb_column_padding=”true” content_placement=”middle”][vc_column thb_color=”thb-light-column” width=”1\/2″ el_class=”text-center” css=”.vc_custom_1579183788608{padding-top: 25% !important;padding-right: 5% !important;padding-bottom: 25% !important;padding-left: 5% !important;background-image: url(https:\/\/lightox.co.uk\/wp-content\/uploads\/2020\/01\/LIGHTOX_HOME.jpg?id=1335) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column_text animation=”animation bottom-to-top”]\n
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    LIGHTOX<\/span>
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    About<\/span><\/span><\/h1>\n\t\t\t\t