LXD191

We are developing a treatment that will be applied directly to the diseased area, in the form of a gel, and is activated using a specific wavelength of light.

We have seen positive results in pre-clinical animal studies and are looking to move into the clinic towards the end of 2021. We envisage this treatment will provide a convenient way of managing patients with oral dysplasia and reduce their risk of developing mouth cancer.

Our Solution

LightOx’s new technologies fundamentally change the way in which light-based therapies are delivered to the patient through a new class of patented small molecule, fluorescent, drug-like compounds which overcome the limitations of current light-based treatments.

Particularly appropriate for the treatment of pre-cancerous and early stage oral cancer, this light-based therapeutic treatment minimises side-effects for patients and is less invasive than surgery.

Apply

Small compound size suitable for topical formulation
Cell penetration using small molecule drug

Detect

Directed light illuminates compromised area
Drug localises in compromised tissue and fluoresces at specific wavelength

Target

The cancerous area is identified
There is minimal collateral damage

Treat

Increased light power on targeted area activates cell killing
Natural mechanism: ROS production leads to cell apoptosis

The treatment could be as simple as: dentist’s standard oral inspection, in-surgery treatment, repeated as necessary, with no problems associated with radiation therapy.

Early identification of oral squamous cell carcinoma with instant treatment by inducing apoptosis (natural cell death) of the selected cells and tissues with minimal damage to healthy cells.

Important advancements include:

  1. Selective targeting for cancer cells as opposed to healthy cells
  2. Small molecular size for topical application
  3. Minimal off-target toxicity
  4. Dual diagnostic and treatment agents
  5. Non-toxic drugs in the absence of light activation at specific wavelengths
  6. Rapid take-up in cancer cells, reducing the exposure time to the drug and speeding up light-based treatment times
  7. Not activated by sunlight, minimising patient impact

By using light-based treatment, our new phototherapeutic drugs target the particular and desired body sites, using simple delivery systems, enabling rapid treatment and ensuing cell death of specific cells and tissues.

We are building relationships with clinicians working in the oral cancer and phototherapeutic areas to ensure that our ongoing development programme keeps patients at the heart of everything we do, while ensuring that our novel treatment ass are simple and user-friendly as possible for both clinicians to use and patients to experience.

We are actively seeking new partners in the area of Head and Neck cancer especially those who have experience working with Photodynamic Therapies.

Get in touch to start a conversation with our team

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IMAGING PROBES

Probes

A Unique Range of Molecular Tools for use in Imaging, Therapeutics and Assay Development.
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LIGHTOX

About

Our technologies lie in the design and synthesis of new chemical entities, tailoring molecular properties to the required application.
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