THERAPEUTICS   I   ORAL CANCER

Oral cancers are the sixth most common cancers worldwide with over 350,000 new cases in 2020.

Oral cancer incidence is increasing globally and is strongly related to age, with the highest incidence rates in older populations. More than 2/3 of those diagnosed are men.
Significant Risk Factors

Although it is not known what causes all oral cancers there are some significant risk factors that increase the chances of developing them.

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SMOKING

More than 60% of mouth & oropharyngeal cancers are caused by smoking.

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DRINKING

Around 30% of mouth & oropharyngeal cancers are caused by drinking alcohol.

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HPV

Around 70% of oropharyngeal cancers are linked to human papillomavirus (HPV).

Oral Cavity Cancer

Cost of Care

USA 2018

4,493 dead
24,229 diagnosed
Cost of care 2009 USD per head

$50K-$80K

INDIA 2018

72,616 dead
119,992 diagnosed
Cost of care 2015 USD per head

$3K-$15K

CHINA 2018

14,000 dead
27,700 diagnosed
Cost of care 2009 USD per head

$71 MILLION

CURRENT TREATMENT

Standard first-line treatment in 95% of cases of oral cancer is surgery with a 1 cm of healthy tissue removed along with the cancerous tissue.

Surgery will leave the patient with significantly altered appearance and lifelong functional defects in most cases, including speech impediments, and difficulty in chewing, swallowing and eating. 2 in 5 will die within 5 years which is a higher mortality rate than prostate or cervical cancers.

Patients report severely compromised quality of life more than 12 months after treatment and therefore, follow-on treatment is necessary such as chemotherapy and radiation that can damage healthy cells. These treatments can also cause side-effects such as hair loss, mouth sore, and vomiting.

Oral Cancer Treatment Options

Stage 1, UK 2012-15
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Surgery

1cm of healthy tissue removed

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Radiotherapy

Jaw damage, dry mouth

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Chemotherapy

Immune system compromised

Information provided by the World Health Organisation

We are developing therapeutics to target the most common oral cancer using a simple gel-based local delivery system that is activated by light.

This enables instant treatment by inducing apoptosis (natural cell death) of the selected cells and tissues with minimal damage to healthy cells.
Our Solution
IMAGING PROBES

Probes

A Unique Range of Molecular Tools for use in Imaging, Therapeutics and Assay Development.
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RESEARCH TOOLS

PhotoReact

The PhotoReact 365nm is versatile and compliments LightOx’s range of probes already available through Merck.
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