LightOx™17

≥98% (HPLC)
Retinoic Acid Analogue & Conjugation

Biochemical/Physiological Actions

Strong ligand for retinoic acid receptor (RAR) proteins

Applications

• Fluorescence Microscopy
• Fluorescence Spectroscopy

Features and Benefits

LightOx™17 is a fluorescent molecule that exhibits solvatochromatic fluorescence emission when excited with UV-A and violet (405 nm) light sources.

In a cellular environment it exhibits predominately mitochrondrial localisation and, when activated by UV-A or 405 nm absorption wavelengths, elicits the release of reactive oxygen species (ROS) for controlled, localised cell death.

Papers

LightOx™17 is referred to as DC324 in the following papers

Fluorescent Retinoic Acid Analogues as Probes for Biochemical and Intracellular Characterization of Retinoid Signaling Pathways

Photoactivated cell-killing involving a low molecular weight, donor–acceptor diphenylacetylene

A Bioluminescence Reporter Assay for Retinoic Acid Control of Translation of the GluR1 Subunit of the AMPA Glutamate Receptor

Genomic and non-genomic pathways are both crucial for peak induction of neurite outgrowth by retinoids

CYP26A1 gene promoter is a useful tool for reporting RAR-mediated retinoid activity